Born in 1973 in Groningen, the Netherlands, Paul de Bie studied at the Minerva School of Fine Arts in the same city, where he specialized in lithography and drawing. On completing his degree in 1998, his work was nominated for the Hendrik de Vries Stipendium, and 1999 he was commissioned to create a series of sculptures for the Academic Hospital of Groningen.

Since then, his interests have shifted towards painting, and in 2004 a collection of his work was exhibited at the Horst Janssen Museum in Oldenburg, Germany. He moved to Paris, Antwerp and finally ended up Barcelona where he lived and worked for about eight years.

After moving back to his hometown in 2011 he started portraying retired professors for the University Museum. In 2013 he painted a portrait of the city's mayor and starred in the television-contest 'Sterren op het Doek', creating a portrait of Dutch actress Ellen Vogel. The following year he started designing posters for classical concerts of the Oosterpoort Music Hall and in 2016 won the public prize of the 'AVRO/TROS' art contest with his painting 'Sabina's Room', which was exhibited in Museum de Fundatie in Zwolle.

In more recent years, he has been focusing on commissioned portraits and painting murals, while his work was used for several book covers. In 2021 he started writing and illustrating a fiction novel which came out in 2025.